IVAL Publications
IdMOC
- Cytotoxicity of eight cigarette smoke condensates in three test systems: comparisons between assays and condensates
- The use of the integrated discrete multiple organ co-culture (IdMOC) system for the evaluation of multiple organ toxicity
- In vitro evaluation of human xenobiotic toxicity: scientific concepts and the novel integrated discrete multiple cell co-culture (IdMOC) technology
- Human hepatocytes: isolation, cryopreservation and applications in drug development
- A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells
- Non-Animal Methodologies within Biomedical Research and Toxicity Testing
Metabolism
- Preclinical in vitro screening assays for drug-like properties
- Estrogen sulfotransferase expression in the human liver
- Screening for human ADME/Tox drug properties in drug discovery.
- In vitro approaches to evaluate ADMET drug properties.
Toxicity
- Applications of microarrays with toxicologically relevant genes
- Accurate prediction of human drug toxicity: a major challenge in drug development
- A comprehensive approach to drug safety evaluation.
Posters
- A Novel Human Hepatocyte Culture Medium for the Maintenance of P450, Uptake Transporters, and Efflux Transporters
- Integrated Discrete Multiple Organ Co-culture (IdMOC) System for the Evaluation of Multiple Organ Drug Distribution, Drug Metabolism, and Organ Specific Drug Toxicity
- A Novel Cellular Model for Drug-induced Adipogenesis
- Regulation of P450 enzymes and Drug Transporter Expression in Human Hepatocytes Exposed to Cytokine Interleukin-6
- Effects of prototypical drug inducers on drug metabolizing enzyme and transporter gene expression in human hepatocytes
- Evaluation of the Effects of Inflammatory Cytokines on Drug-induced Liver Injury (DILI) in Human Hepatocytes
- Comparison of Induction of CYP1A and CYP3A Gene Expression by Prototypical Drug Inducers in Primary Culture of Human and Monkey Hepatocytes
- The Integrated Discrete Multiple Organ (IdMOCTM) Technology as an In Vitro Model For Systems Toxicology